Podcast: New Strategies for Clinical Trials in Autism Spectrum Disorder

Bentham Science

Author(s): Rini Pauly, Catherine A. Ziats, Ludovico Abenavoli, Charles E. Schwartz, Luigi Boccuto*

Journal Name:Reviews on Recent Clinical Trials

Abstract:

Background: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that poses several challenges in terms of clinical diagnosis and investigation of molecular etiology. The lack of knowledge on the pathogenic mechanisms underlying ASD has hampered the clinical trials that so far have tried to target ASD behavioral symptoms. In order to improve our understanding of the molecular abnormalities associated with ASD, a deeper and more extensive genetic profiling of targeted individuals with ASD was needed.

Methods: The recent availability of new and more powerful sequencing technologies (third-generation sequencing) has allowed to develop novel strategies for characterization of comprehensive genetic profiles of individuals with ASD. In particular, this review will describe integrated approaches based on the combination of various omics technologies that will lead to a better stratification of…

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Published by Autism Candles

My name is Nathan Young. I'm the founder of the Autism Candles project. I am a self-advocate. The candle project exist to make a statement about inclusion and opportunity. My email is nathan@autismcandles.com. Feel free to contact me. https://www.autismcandles.com

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